ECD
- E. C. Drury School for the Deaf
- ECD (gene)
- ECD Corporation
- Early childhood development
- Eastern Caribbean dollar
- Eastern Continental Divide
- Economic Crime Department
- Electron capture detector
- Electron-capture dissociation
- Electronic Commerce Directive 2000
- Electronic Control Device
- Electronic civil disobedience
- Energy Citations Database
- Energy Conversion Devices
- English country dance
- Equine Cushing's disease
- Erdheim–Chester disease
- EuroCity
- Evidence Centered Design
- Expanded criteria donor
- Explanatory combinatorial dictionary