EAC
- Carbon dioxide scrubber
- EA Canada
- EAC-C2C
- East African Community
- East Asian Community
- East Asiatic Company
- East Australian Current
- Eastern Agricultural Complex
- Eastern Air Command (India)
- Eastern Arizona College
- Easy Anti-Cheat
- Echelon above corps
- Ecology Action Centre
- Editors' Association of Canada
- Ehrlich ascites carcinoma
- Eko Atlantic
- Election Assistance Commission
- Electoral Affairs Commission
- Electricity Authority of Cambodia
- Electricity Authority of Cyprus
- Emilio Aguinaldo College
- Encoded Archival Context
- Energy Action Coalition
- Enhanced Audio Codec
- Environmental audit committee
- Equivalent annual cost
- Erythema annulare centrifugum
- Esophageal adenocarcinoma
- Eurasian Conformity mark
- Euro-American Challenge
- Euro-Atlantic Centre
- Europae Archaeologiae Consilium
- European Advisory Commission
- European Air Charter (Bulgarian airline)
- European Arboricultural Council
- European Archery Championships
- European Astronaut Centre
- European Astronaut Corps
- European Asylum Curriculum
- European Athletics Championships
- European Aviation Air Charter
- Everyone's a Critic
- Exact Audio Copy
- Extended Access Control
- External auditory canal
- FAI European Aerobatic Championships
- RCAF Eastern Air Command