DRS
- DRS (band)
- DRS Technologies
- Dandot railway station
- Davis Renov Stahler Yeshiva High School for Boys
- Dead Runners Society
- Decision Review System
- Defensive Runs Saved
- Deposit-refund system
- Design Research Society
- Diffuse reflectance spectroscopy
- Direct Rail Services
- Direct holding system
- Discourse representation structure
- Doctor (title)
- Drag reduction system
- Dresden Airport
- Drought Relief Service
- Dundonald railway station
- Dynamic resolution scaling
- Département du Renseignement et de la Sécurité
- ICL DRS
- MC D.R.S.
- Master of Science
- SF DRS
- Schweizer Radio DRS
- VMware Infrastructure