Dixyrazine


Dixyrazine, also known as dixypazin, sold under the brand names Ansiolene, Esocalm, Esucos, Metronal, and Roscal, is a typical antipsychotic of the phenothiazine group described as a neuroleptic and antihistamine. It was first introduced in Germany in 1969. It is used as a neuroleptic, anxiolytic, and antihistamine in doses between 12.5 and 75 mg a day.

Synthesis

Sodamide alkylation of phenothiazine with 1-bromo-3-chloro-2-methylpropane gives 10-phenothiazine. Completion of the sidechain by alkylation with 1-piperazine and displacement of the halogen completes the synthesis of dixyrazine.