Death receptor 4
Death receptor 4, also known as TRAIL receptor 1 and tumor necrosis factor receptor superfamily member 10A, is a cell [surface receptor] of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.
Function
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand, and thus transduces cell death signal and induces cell apoptosis.Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.