De Villegas
De Villegas is a surname. Notable people with the surname include:
- Andrés Rodríguez de Villegas, Spanish colonial governor
- Diogo Ortiz de Villegas, Spanish Roman Catholic priest
- Esteban Manuel de Villegas, Spanish poet
- Hipólito de Villegas, Chilean politician
- Pedro Ruiz de Villegas II, Spanish noble
- Pedro de Villegas Marmolejo, Spanish Renaissance sculptor and painter
- Maria de Villegas de Saint-Pierre, Belgian Countess, writer, nurse and philanthropist