De Güemes
De Güemes is a surname, and may refer to:
- Juan Francisco de Güemes y Horcasitas, 1st Count of Revillagigedo, Spanish general, governor of Havana, captain general of Cuba, and viceroy of New Spain
- Juan Vicente de Güemes Padilla Horcasitas y Aguayo, 2nd Count of Revillagigedo, Spanish military officer and viceroy of New Spain
- Martín Miguel de Güemes, military leader