Frank was born to Sylvia Tobacco and Darrell Two Crow. Her Lakota name, Ta Oyate Wiyankapi Win translates to Her People See Her. Frank's maternal grandparents were Stephen “Psin” Tobacco and Caroline Catches Tobacco. Her paternal grandparents were Justin “Judson” Two Crow and Anna “Annie” Chief Eagle-Two Crow. She is a member of the Oglala Sioux and was raised on the Pine Ridge Indian Reservation.