David Spence
David Spence may refer to:
- David Spence (VC), Scottish recipient of the Victoria Cross
- David Spence (Canadian politician), member of the Canadian House of Commons
- Dave Spence, candidate for governor in Missouri
- David Spence (Manitoba politician), politician in Manitoba, Canada
- David Spence (mathematician), New Zealand and British mathematician
- David Spence (rubber chemistry), pioneer in the field of rubber chemistry
- Dave Spence (cricketer), New Zealand cricketer
- David Jerome Spence, Canadian architect, designer of such buildings as Montreal's Martlet House
- David H. N. Spence British botanist