Devadoss married Masilamoney Chellammal, the daughter of J.T. Srinivasagen Pillai. She died in 1948. David Devadoss died in Madras on 11 July 1955, at the age of 86. Their children were Seetha, Muthamma, Vedha, and Muthukrishnan. Only Vedha married Raja Rhenius. They had one son, Jayanth Rhenius.