Daphnetin

Daphnetin is a chemical compound with the molecular formula. It has been isolated from plants of the genus Daphne. It has also been found in Matricaria chamomilla.
It a crystalline solid with a melting point of 256 °C. It is soluble in boiling water.
Daphnetin can undergo enzymatic glycosylation to yield its 7-O-glucoside which is called daphnin. The reaction is catalyzed by the enzyme O-dihydroxy coumarin 7-O-glucosyltransferase.
Daphnetin shows several neuroprotective and anti-inflammatory effects on the inhibition of the TLR4/NF-κB mediated inflammatory signaling pathway. They also could inhibit the IKKs/IkBa/NF-κB, AKT, and the Src/FAK/ERK1/2 multi-target medication signaling pathway for anti-angiogenesis and cancer.
Daphnetin has been reported to be a strong sensitizer, which means that this compound and its glycosidic derivatives can be a cause of allergic reactions.