DSS
- Blaise Diagne International Airport
- Child Protective Services
- DS2 (disambiguation)
- DSS (NMR standard)
- Dansk Spejderkorps Sydslesvig
- Darwin Streaming Server
- Dead Sea Scrolls
- Decision support system
- Deep Space Network
- Defense Security Service
- Dejerine Sottas syndrome
- Delta Secondary School (Delta, British Columbia)
- Democratic Party of Serbia
- Democratic Serb Party (Montenegro)
- Demographic surveillance system
- Dengue shock syndrome
- Department of Social Security (Australia)
- Department of Social Security (United Kingdom)
- Department of Social Services (Australia)
- Dera Sacha Sauda
- Design for Six Sigma
- Dextran sulphate sodium
- Digital Satellite Service
- Digital Signature Services
- Digital Signature Standard
- Digital Speech Standard
- Digital Subscriber System No. 1
- Digital Subscriber System No. 2
- Digitized Sky Survey
- Dioctyl sodium sulfosuccinate
- Diplomatic Security Service
- Direct Subsidy Scheme
- Disease-specific survival
- Disuccinimidyl suberate
- Dizionario Storico della Svizzera
- Domestic Security Section
- Drahtseilbahn Schwyz–Stoos
- Duplex Stainless Steel
- Enver Hoxha
- Integrated Services Digital Network
- Knightswood Secondary School
- Ramiz Alia
- Securitate
- Selective Service System
- Sigurimi
- State Security Service (Nigeria)
- United Nations Department for Safety and Security