DSC
- DECT Standard Cipher
- DSC International School, Hong Kong
- Daily Source Code
- Dallas Symphony Chorus
- Dalton State College
- Dave, Shelly, and Chainsaw
- Daytona State College
- Deep South Conference
- Deep Springs College
- DeepSouthCon
- Defence Security Corps
- Defense Security Command
- Delbrücker SC
- Dice similarity coefficient
- Differential scanning calorimetry
- Digital selective calling
- Digital setting circles
- Digital signal controller
- Digital still camera
- Directory of Social Change
- Display Stream Compression
- Distinguished Service Cross (Australia)
- Distinguished Service Cross (United Kingdom)
- Distinguished Service Cross (United States)
- Distributed source coding
- District Selection Committee
- Dixie State College
- Doctor of Science
- Doctor of Surgical Chiropody
- Document Structuring Conventions
- Dollar Shave Club
- Doppler shift compensation
- Down Syndrome Centre
- Dresdner SC
- Dschang Airport
- Dubai Sports City
- Dutch Swing College Band
- Dyal Singh College, Delhi
- Dye-sensitized solar cell
- Dynamic stability control
- PowerShell
- Subarctic climate
- U.S. Postal Service Pro Cycling Team
- United States District Court for the District of South Carolina