2,5-Dimethoxy-4-isobutylamphetamine
2,5-Dimethoxy-4-isobutylamphetamine is a serotonin 5-HT2A receptor agonist, serotonergic psychedelic, and anti-inflammatory drug of the phenethylamine, amphetamine, and DOx families.
Use and effects
DOIB is active at doses of 10 to 15mg orally, and hence is about one-third as potent as DOM.Pharmacology
DOIB is a full agonist of the serotonin 5-HT2A receptor, with an of 12.6nM and an of 98.8%, both for calcium mobilization. It is about one-third as potent as DOM in rodent drug discrimination tests and also substitutes for LSD in these tests. In addition to its psychedelic effects, DOIB has highly potent anti-inflammatory effects in preclinical research. It was more potent than almost any other tested psychedelic. The drug was notably more potent than (R)-DOI, but was less potent than 2C-I.Chemistry
Analogues
DOIB is part of the series of straight-chain and branched-chain 4-alkylated DOx drugs that also includes DOM, DOET, DOPR, DOBU, DOAM, and DOHx, among others.Some other notable analogues of DOIB include DOBU, DOSB, and DOTB.