DOB-NBOMe
DOB-NBOMe, or NBOMe-DOB, also known as N--4-bromo-2,5-dimethoxyamphetamine, is a serotonin 5-HT2A receptor agonist and possible psychedelic drug of the phenethylamine, DOx, and 25-NB families. It is the N- derivative of DOB and the amphetamine analogue of 25B-NBOMe.Pharmacology
The drug is a potent serotonin 5-HT2A receptor partial agonist, with an of 7.94nM and an of 20% in the employed assay. As an agonist of the serotonin 5-HT2A receptor, DOB-NBOMe had about the same potency as DOB but had greatly reduced efficacy in comparison in vitro. Compared to 25B-NBOMe, the corresponding NBOMe analogue of 2C-B, DOB-NBOMe had about 30-fold lower potency as a serotonin 5-HT2A receptor agonist and about half the activational efficacy. Whereas the potency of 2Cs can be dramatically increased by N- substitution, this has not been the case with the DOx series of psychedelics, where activity has been negatively impacted.History
DOB-NBOMe was first described in the scientific literature by Ralf Heim by 2003.