DME
- DME (psychedelic)
- DME Academy
- Dakota, Minnesota and Eastern Railroad
- Dashtop mobile equipment
- Delhi–Mumbai Expressway
- Design Management Europe Award
- Diabetic macular edema
- Diastatic malt extract
- Dimethoxyethane
- Dimethyl ether
- Dimethylethanolamine
- Disney's Magical Express
- Distance measuring equipment
- Dropping mercury electrode
- Dubai Mercantile Exchange
- Durable medical equipment
- ICL Direct Machine Environment
- Moscow Domodedovo Airport
- United States District Court for the District of Maine
- Ɗugwor language