DES
- Arizona Department of Economic Security
- Bachelor of Design
- Dar es Salaam
- Dark Energy Survey
- Data Encryption Standard
- Deccan Education Society
- Deep Ecliptic Survey
- Deep eutectic solvent
- Defence Equipment and Support
- Delivered Ex Ship
- Department of Education and Science (UK)
- Department of Social Services (Australia)
- Des (TV series)
- Desh (disambiguation)
- Desi (disambiguation)
- Desiree (given name)
- Desmond (name)
- Desroches Airport
- Detached eddy simulation
- Diethyl sulfate
- Diethylstilbestrol
- Diffuse esophageal spasm
- DirectShow Editing Services
- Discrete event simulation
- Dissociative Experiences Scale
- Drug-eluting stent
- Dysequilibrium syndrome