Daf-12
The DAF-12 gene encodes the nuclear receptor of dafachronic acid in the worm Caenorhabditis elegans, with the NRNC Symbol NR1J1 as the homolog of Nuclear hormone receptor HR96 in D. melanogaster. DAF-12 has been implicated by Cynthia Kenyon and colleagues related to the formation of Dauer larva.
In favorable environments, a cytochrome p450 Daf-9 produce Dafachronic Acid to bingding Daf-12 to initiating downstream gene expression. When in infavorable environments, like starve, Dafachronic Acid decreases, Daf-12 will form a complex with co-repressor DIN-1.
