[Image:Coptis aspleniifolia.jpg|thumb|Coptis aspleniifolia leaves]The species inhabits warm and cold temperate forests of oak-rhododendron association. It is occasionally seen growing under bamboo thickets around Mayodia region of Dibang Valley district in the Mishmi Hills of Arunachal Pradesh in India. It flowers during early spring March–April and sets fruit/seed in July–August. The seedlings are rare and are often found germinating on moss laden dead wood on the forest floor or even on moss laden branches of Rhododendron. A new subspecies was recognised in C. teeta by Pandit & Babu and was named as subsp. lohitensis, which is morphologically very different from subsp. teeta and it is geographically distinct and inhabits broad leafforests in Delai Valley of Lohit district in Arunachal Pradesh, India.