Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy
Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy is a scholarly work by Aris Economides, published in 2004 in ''Molecular and Cellular Biology''. The main subjects of the publication include biology, spinal muscular atrophy, muscle atrophy, endocrinology, ITGA7, mechanistic target of rapamycin kinase, protein kinase B, atrophy, signal transduction, muscle hypertrophy, adipose tissue, histone deacetylases, sarcopenia, skeletal muscle, and internal medicine. The authors describe here the use of a novel method to produce a transgenic mouse in which a constitutively active form of Akt can be inducibly expressed in adult skeletal muscle and thereby demonstrate that acute activation of Akt is sufficient to induce rapid and significant skeletal muscle hypertrophy in vivo, accompanied by activation of the downstream Akt/p70S6 kinase protein synthesis pathway.