Comparison of psychoactive alcohols in alcoholic drinks


Comparison of psychoactive alcohols in alcoholic beverages.
The Lucas test in alcohols is a test to differentiate between primary, secondary, and tertiary alcohols.

General

IUPAC nameCommon nameClassificationCAS
EthanolAlcohol, drinking alcohol, ethyl alcohol, EtOHPrimary64-17-5
Propan-1-ol1-Propanol, 1-propyl alcohol, PrOHPrimary71-23-8
2-ethanolTryptopholPrimary526-55-6
2-Methylbutan-1-ol2-Methyl-1-butanol Secondary137-32-6
2-methylpropan-1-ol2-Methyl-1-propanol, IsobutanolPrimary78-83-1
2-Methylbutan-2-ol2-Methyl-2-butanol, tert-Amyl alcohol Tertiary75-85-4
2-Methylpropan-2-ol2-Methyl-2-propanol, tert-Butyl alcohol, t-BuOHTertiary75-65-0
2-Phenylethan-1-olPhenethyl alcohol, 2-PhenylethanolPrimary60-12-8
3-Methylbutan-1-ol3-methyl-1-butanol, isoamyl alcohol, isopentyl alcohol Primary123-51-3

Pharmacology

IUPAC nameIARC carcinogen groupToxic metaboliteAlcohol by volume LD50 in rat, oral
EthanolGroup 1Acetaldehyde → acetic acidUp to 95.6% in rectified spirit7060 mg/kg
Propan-1-olPropionaldehyde → propionic acid2.8% in Jamaican rum: 2384–3130 mg/100 mL. Up to 3500 mg/L in spirits.1870 mg/kg
2-ethanol???
2-Methylbutan-1-ol?1.2% in Bourbon: 910–1390 mg/100 mL4170 mg/kg
2-methylpropan-1-ol?0.9% in Rye mash cistern room: 534–1197 mg/100 mL2460 mg/kg
2-Methylbutan-2-olNone 0.07% in beer: 70 mg/100 mL Found in cassava fermented drinks1000 mg/kg
2-Methylpropan-2-olNone Identified, not quantified, in beer2743 mg/kg
2-Phenylethan-1-ol?0.1% in non-yeasted cider : 100 mg/100 mL1790 mg/kg
3-Methylbutan-1-ol?1.5% in French Brandy: 859–2108 mg/100 mL1300 mg/kg