| Format name | Operating system | Filename extension | Explicit processor declarations | Arbitrary sections | Metadata | Digital signature | String table | Symbol table | 64-bit | Fat binaries | Can contain icon |
| ELF | Unix-like, OpenVMS, BeOS from R4 onwards, Haiku, SerenityOS | none | by file | | | | | | | | |
| PE | Windows, ReactOS, HX DOS Extender, BeOS | .EXE | by file | | | | | | | | |
| PE32+ | Windows | .EXE | by file | | | | | | | | |
| Mach-O | NeXTSTEP, macOS, iOS, iPadOS, watchOS, tvOS, visionOS | none | by file or subfile of a multi-architecture binary | | | | | | | | |
| OS/360 | OS/360 and successors, and VS/9, mainframe operating systems | none | | | | | | | | | |
| GOFF | IBM MVS and z/OS mainframe operating systems | none | | | | | | | | | |
| a.out | Unix-like | none | | | | | | | | | |
| COFF | Unix-like | none | by file | | | | | | | | |
| ECOFF | Ultrix, Tru64 UNIX, IRIX | none | by file | | | | | | | | |
| XCOFF | IBM AIX, BeOS, "classic" Mac OS | none | by file | | | | | | | | |
| SOM | HP-UX, MPE/ix | | | | | | | | | | |
| Amiga Hunk | AmigaOS | none | | | | | | | | | |
| PEF | "classic" Mac OS, BeOS | none | by file | | | | | | | | |
| CMD | CP/M-86, MP/M-86, Concurrent CP/M-86, Personal CP/M-86, S5-DOS, Concurrent DOS, Concurrent DOS 286, FlexOS, S5-DOS/ST, S5-DOS/MT, Concurrent DOS 386, Multiuser DOS, System Manager, REAL/32, DOS Plus | .CMD | | | | | | | | | |
| FlexOS 186 | FlexOS 186, FlexOS 286, S5-DOS/ST, S5-DOS/MT, 4680 OS, FlexOS 386, 4690 OS | .186 | | | | | | | | | |
| FlexOS 286 | FlexOS 286, S5-DOS/ST, S5-DOS/MT, 4680 OS, FlexOS 386, 4690 OS | .286 | | | | | | | | | |
| CP/M-68K | CP/M-68K, Concurrent DOS 68K, FlexOS 68K | .68K | | | | | | | | | |
| COM (CP/M) | CP/M, MP/M, Concurrent CP/M, Personal CP/M | .COM | | | | | | | | | |
| COM (DOS) | DOS, OS/2, Windows, Concurrent CP/M-86, Concurrent DOS, Concurrent DOS 286, FlexOS, Concurrent DOS 386, Multiuser DOS, System Manager, REAL/32, DOS Plus | .COM | | | | | | | | | |
| MZ (DOS) | DOS, OS/2, Windows, Concurrent DOS 286, FlexOS, Concurrent DOS 386, Multiuser DOS, System Manager, REAL/32, DOS Plus | .EXE | | | | | | | | | |
| MZ | GEM, ViewMAX | .APP/.ACC | | | | | | | | | |
| NE | MS-DOS 4.0 (multitasking), OS/2, Windows, HX DOS Extender | .EXE | | | | | | | | | |
| LE, | OS/2, some DOS extenders | .EXE | by file | | | | | | | | |
| LX | OS/2, some 32-bit DOS extenders | .EXE | by file | | | | | | | | |
| PIM/XIP | PalmDOS | .PIM/.XIP | | | | | | | | | |
| DL | MS-DOS System Manager applications | .EXM | | | | | | | | | |
| MP | Phar Lap DOS extenders | .EXP | | | | | | | | | |
| P2 | Phar Lap 16-bit DOS extenders | .EXP | | | | | | | | | |
| P3 | Phar Lap 32-bit DOS extenders | .EXP | | | | | | | | | |
| GEOS | PC/GEOS, Geoworks Ensemble, NewDeal Office, Breadbox Ensemble | .GEO | | | | | | | | | |