The route begins at US 550 in Silverton and runs for to its terminus at a CDOT maintenance yard.
History
The route was established in the 1920s, when it began at US 550 in Silverton and headed north to Howardsville. SH 110 was extended north to Eureka by 1938. The northern terminus was moved to Gladstone in 1961. Except for the left today, the entire route was deleted north of Silverton in 2003; signage was removed along the entire route. On November 24, 2006, CDOT no longer called SH 110 a real part of the state highway system; SH 110 still exists.