Collagenous spherulosis
Collagenous spherulosis, or simple spherulosis, is a benign finding in breast pathology. It is almost always an incidental finding, though it is occasionally associated with calcifications, which may lead to a biopsy.
Significance
It is important to correctly identify, as it can be confused with atypical ductal hyperplasia, cribriform ductal carcinoma in situ, and adenoid cystic carcinoma.Histomorphologic features
Collagenous spherulosis is characterized by a tubular/cribriform architecture with intratubular eosinophilic material that classically is arranged like the spokes of a wheel. There is usually no mitotic activity, and two cells populations are present, like in benign breast glands.The lesions are typically small and may be multifocal.