Clotiapine

Clotiapine is an atypical antipsychotic of the dibenzothiazepine chemical class. It was first introduced in a few European countries, Argentina, Taiwan and Israel in 1970.
Some sources regard clotiapine as a typical antipsychotic rather than atypical due to its high incidence of extrapyramidal [side effects] compared to the atypicals like clozapine and quetiapine, to which it is structurally related. Despite the relativity high rate of undesired effects it has demonstrated efficacy in treatment-resistant individuals with schizophrenia according to a number of psychiatrists with clinical experience with it, some weak clinical evidence supports this view too. A systematic review performed by Cochrane compared clotiapine with other antipsychotic drugs:
A fatal case of urinary retention associated with this drug has been reported in literature.