Clobetasone

Clobetasone is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema, psoriasis and other forms of dermatitis, and ophthalmology. Topical clobetasone butyrate has shown minimal suppression of the hypothalamic–pituitary–adrenal axis.
It is available as clobetasone butyrate under the brand names Eumosone or Eumovate both manufactured by GlaxoSmithKline.
Trimovate also contains oxytetracycline, an antibiotic, and nystatin, an antifungal.

Uses

In dermatology, topical clobetasone butyrate helps to reduce the itchiness and erythema associated with eczema and dermatitis.
In ophthalmology, clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes in Sjögren syndrome. Sjögren syndrome is an autoimmune disorder that affects the moisture producing glands of the body causing many symptoms including dry eyes. When compared to other corticosteroid eye drops; clobetasone butyrate showed only minimal rises in intraocular pressure. Increased pressure within the eye can lead to glaucoma.

Side effects associated with clobetasone cream and ointment include: burning, irritation, itching, thinning of the skin, and changes in skin color.

The following should not be treated with clobetasone with nystatin and oxytetracycline:

Patients with known history of hypersensitivity to clobetasone butyrate, nystatin, oxytetracycline or any components of the formulation
Primary cutaneous viral infections
Primary infected skin lesions caused by infection with fungi, bacteria or yeasts
Cutaneous infections caused by Acinetobacter species, methicillin resistant Staphylococcus aureus, Pseudomonas species, Proteus species Serratia species or Group B streptococcal infection
Rosacea
Acne vulgaris
Pruritus without inflammation

Pseudomembranous colitis - C. Diff. Colitis, also called: Clostridioides difficile colitis, or Pseudomembranous colitis has been reported with the use of antibiotics and may range in severity from mild to life-threatening.
Reversible hypothalamic-pituitary-adrenal axis suppression - Manifestations of hypercortisolism and reversible hypothalamic-pituitary-adrenal axis suppression can occur in some individuals as a result of increased systemic absorption of topical corticosteroids.