Clinodactyly
Clinodactyly is a medical term describing the curvature of a digit in the plane of the palm, most commonly the fifth finger towards the adjacent fourth finger.
It is a fairly common isolated anomaly which often goes unnoticed, but also occurs in combination with other abnormalities in certain genetic syndromes. The term comes.
Genetics
Clinodactyly is an autosomal dominant trait that has variable expressiveness and incomplete penetrance.Clinodactyly can be passed through inheritance and presents as either an isolated anomaly or a component manifestation of a genetic syndrome. Many syndromes are associated with clinodactyly, including those listed below. But the phenotype, by itself, is not a sensitive or specific diagnostic test for these syndromes.
- Down syndrome
- Turner syndrome
- Aarskog syndrome
- Carpenter syndrome
- Seckel syndrome
- Cornelia de Lange syndrome
- Orofaciodigital syndrome 1
- 13q deletion syndrome
- XXYY syndrome
- Silver–Russell syndrome
- Noonan syndrome
- Ehlers–Danlos syndrome
- Andersen–Tawil syndrome