CLE
- Canadian Lakehead Exhibition
- Central Landing Establishment
- Chemical Langevin equation
- Chu–Liu/Edmonds algorithm
- Claire's
- Cle Jeltes
- Cle Newhook
- Cle Shaheed Sloan
- Clear lens extraction
- Clementi MRT station
- Cleveland
- Cleveland Browns
- Cleveland Cavaliers
- Cleveland Guardians
- Cleveland Hopkins International Airport
- Clé (footballer)
- Clé Bennett
- Conformal loop ensemble
- Congenital lobar emphysema
- Consistent life ethic
- Continuing legal education
- Leukoencephalopathy with vanishing white matter
- Major League Baseball
- Mercedes-Benz CLE
- National Basketball Association
- National Football League
- National Weather Service
- Stray Kids