Clay High School
- Ashland, Alabama
- Clay Center High School (Nebraska)
- Clay Center, Kansas
- Clay Central–Everly Community School District
- Clay City Junior-Senior High School
- Clay City, Illinois
- Clay City, Indiana
- Clay County High School (Kentucky)
- Clay High School (Green Cove Springs, Florida)
- Clay High School (Oregon, Ohio)
- Clay High School (Portsmouth, Ohio)
- Clay High School (South Bend, Indiana)
- Clay, West Virginia
- Clay-Battelle High School
- Clay-Chalkville High School
- Cuthbert, Georgia
- Everly, Iowa
- Henry Clay High School
- Louisville, Illinois
- Lynchburg-Clay High School
- Manchester, Kentucky