Citenamide


Citenamide is a tricyclic chemical agent that is very similar in character to and most closely resembles carbamazepine, which a non-addictive anticonvulsant agent used to treat epileptic seizures, schizophrenia, phantom limb pain and alcoholism. Citenamide contains an amide functional group whereas carbamazepine contains a urea. Citenamide is an old drug and there is little pharmacological data surrounding its use in medicine.

Synthesis

Organometallic formation between 5-chlorodibenzosuberene and butyl lithium, is proceeded by a dry ice quench to give the acid, PC12515652. Halogenation with thionyl chloride and Schotten-Baumann reaction with ammonia gives the amide, and hence citenamide.