Chronic allograft nephropathy


Chronic allograft nephropathy is a kidney disorder which is the leading cause of kidney transplant failure, occurring months to years after the transplant.

Symptoms and signs

CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.

Pathology

The histopathology is characterized by interstitial fibrosis, tubular atrophy,
fibrotic intimal thickening of arteries and glomerulosclerosis.

Diagnosis

CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.