Chronic Effects of Neurotrauma Consortium
The Chronic Effects of Neurotrauma Consortium is a federally funded research project devised to address the long-term effects of mild traumatic brain injury in military service personnel and Veterans. Announced by President Barack Obama on August 20, 2013, the CENC was one of two major initiatives developed in response to the injuries incurred by U.S. service personnel during Operation Enduring Freedom and Operation Iraqi Freedom. The project is jointly funded in the amount of $62.175 million by the Department of Defense and the Department of Veterans Affairs. The CENC is led by Dr. David X. Cifu of the Virginia Commonwealth University.
Background
In short, critical gaps exist in the literature, with a paucity of prospective, controlled studies on late-life outcomes and neurodegeneration after mTBI and related basic science research. These research gaps are particularly prominent in the injuries and difficulties seen in combat-exposed populations. The existing research, although suggestive, is not rigorous or robust enough to allow for a clear understanding of the relationships, risks, and potential effective interventions for mTBI, chronic symptoms, and neurodegeneration. To date, no controlled prospective longitudinal study has examined the late-life cognitive, behavioral, systemic, and functional effects of TBI of any severity. Given the absence of prospective studies, the association between TBI and early neurodegeneration is merely theoretical, and the actual risk factors and rate/extent of physiologic and clinical decline over time are unknown. It is also unclear whether a single TBI may be enough to begin a degenerative cascade in select individuals or whether a critical number of TBIs is needed to “prime” the central nervous system for degeneration. As the majority of TBIs in the military are mild, prospective studies of cognitive outcomes from mild injury are necessary to determine the long-term risks posed to SMs and Veterans. The potential link between mTBI and the development of early dementia is a significant concern for not only at-risk SMs, Veterans, and their families, but also for DoD and VA resource planning, given the high service utilization in the DoD and VA health systems associated with dementia.Given these gaps in scientific research and knowledge, the military- and Veteran-specific issues involved, and the importance of a uniform approach to this critical set of problems, the Department of Defense and the Department of Veterans Affairs jointly issued a request for proposals to fund a 5-year, $62.175 million project to address these concerns. After a competitive application process, a consortium led by Virginia Commonwealth University prevailed and was announced as the recipient of the award by President Obama on August 20, 2013. At the time of the award, this was the single largest grant ever awarded to Virginia Commonwealth University.