Chloride, MissouriChloride is an unincorporated community in Iron County, in the U.S. state of Missouri. Chloride is located on Big Creek along Missouri Route 49. The community is approximately 1.5 miles south of the lead smelter at Glover.HistoryA post office called Chloride was established in 1904, and remained in operation until 1953. The community's name is a transfer from Chloride, Arizona, the onetime home of an early settler.