Business routes of Interstate 44
Nine business routes of Interstate 44 exist, all of them within the state of Missouri.
Joplin business loop
Interstate 44 Business in Joplin runs north from I-44 along Main Street until it reaches Route 66, where it turns east. It then runs through Duquesne and Duenweg. I-44 Bus. has a diamond interchange with Route 249 between Duquesne and Duenweg.I-44 Bus. is concurrent with other highways for its entire length. From the highway's western terminus to downtown Joplin it is concurrent with Route 43. In downtown Joplin, the highway then turns east onto 7th Street and runs concurrent with Route 66 until I-44/I-49/US 71 near Scotland. It follows the old alignment of US 71.
Major intersections
Sarcoxie business loop
Interstate 44 Business through Sarcoxie begins running south from I-44 concurrent with Route 37. It then splits off at Blackberry Street, which becomes High Street upon entering Sarcoxie. After leaving the town, I-44 Bus. angles northeast and ends at I-44. This road is part of former U.S. Route 166, which preceded I-44 through the area.Mount Vernon business loop
Interstate 44 Business in Mount Vernon runs along Mount Vernon Road. The east half of the highway is concurrent with Route 39. I-44 Bus. runs largely along the former route of US 166.Springfield business loop
Interstate 44 Business in Springfield begins at the eastern terminus of Route 266 and runs east along Chestnut Expressway, intersecting US 160 and Route 13. It then runs along the north edge of downtown Springfield. I-44 Bus. turns north at Glenstone Avenue, concurrent with U.S. Route 65 Business. It then ends where Glenstone meets I-44.Lebanon business loop
Interstate 44 Business in Lebanon began at the westernmost Lebanon exit and ended at the easternmost exit. The route followed former US 66 for its entire length. I-44 Bus. followed Springfield Road, then curved off and became Elm Street. At Jefferson Street, it finally junctioned with Route 5, Route 32, and Route 64. The designation was removed in 2021.Major intersections
Waynesville–St. Robert business loop
Interstate 44 Business in the Waynesville–St. Robert area begins on the westside of Waynesville at exit 156. The road briefly heads north on Ichord Avenue, then heads east on a concurrency with Route 17. The road, at this point, also becomes Historic Route 66. I-44 Bus. continues east, past the Pulaski County Courthouse in the old part of the city. The route then climbs a steep hill and rounds a curve underneath a rock overhang painted like a frog. I-44 Bus. continues into St. Robert, and the lanes split with a Roadside Park between them. It passes on through St. Robert, ending at exit 161, which is also the exit for the Fort Leonard Wood I-44 business spur.;Major intersections
Fort Leonard Wood business spur
Interstate 44 Business is a short route connecting the Waynesville–St. Robert I-44 business loop with the main north gate of Fort Leonard Wood. The highway is lined with businesses and is also called Missouri Avenue, whose name continues into Fort Leonard Wood. It is an old alignment of Route 17.;Major intersections