Charles Upton

• Charles W. Upton, American economist
• Charles H. Upton, politician and statesman from Massachusetts and Virginia
• Charles Upton (poet), American poet, Sufi and metaphysician
• Charles L. Upton, American physician and college football coach
• Charles Upton Lowe, for whom Oculocerebrorenal syndrome or Lowe syndrome was named
• Charles Upton, High Sheriff of Derbyshire in 1809