Charles O'Malley

• Charles O'Malley (Michigan), Irish fur trader and urban founder in Michigan, United States
• Charles Conor O'Malley, Irish surgeon, writer, and Chief of the Name
• Charles Donald O'Malley, American historian of medicine and Latinist
• Charles J. O'Malley, Irish financier and newspaper reporter in the United States
• 1841 novel by Charles Lever