Center of Expertise on Gender Dysphoria
The Center of Expertise on Gender Dysphoria, or the Kennis- en Zorgcentrum Genderdysforie, is a transgender clinic at Amsterdam University Medical Centers, location VUmc in Amsterdam, Netherlands. It opened in 1975 and is one of the largest transgender clinics and research institutes in the world. Initially for adults only, from 1987 onwards, a practice dedicated to adolescents opened in Utrecht.:301 The children's clinic merged with the adult clinic in 2002, moving to Amsterdam.:301-302;
As of 2021, it has treated about 10,000 transgender people since it opened almost 50 years previously. The clinic was first headed by Louis Gooren.
Hormone therapy for transgender women was initially done using high-dose estrogen therapy with oral estrogens. Progestogens were also sometimes included. The antiandrogen and progestogen cyproterone acetate was first used in transgender women by 1977. Its use was standard at the CEGD by 1985.