The game is played from the perspective of a crime scene investigator tasked with solving a series of murders. The player is accompanied by a detective partner named James Burton. Players search for clues using a point-and-click system to explore various locations. Players are then graded on how well they searched and how many "hints" they used to uncover the evidence. Environments are rendered primarily using Full motion video technology. Mini-games serve to break up the FMV segments.
Each episode of casebook received moderately positive reviews, with reviewers praising the game's revival of FMV technology while criticizing the game's mini-games as tedious and not interesting.