Carbamoyl phosphate synthase II
Carbamoyl phosphate synthetase is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in the cytosol. Its systemic name is hydrogen-carbonate:L-glutamine amido-ligase .
In pyrimidine biosynthesis, it serves as the rate-limiting enzyme and catalyzes the following reaction:
It is activated by ATP and PRPP and it is inhibited by UTP
Neither CPSI nor CPSII require biotin as a coenzyme, as seen with most carboxylation reactions.
It is one of the four functional enzymatic domains coded by the CAD gene. The CAD gene is a large gene. It uses a single strand to code for these enzyme jobs. It is classified under.