CRS
- .crs (disambiguation)
- Barycentric and geocentric celestial reference systems
- Blue Shirts Society
- CRS-1 (disambiguation)
- Cambridge Reference Sequence
- Camp Rising Sun (New York)
- Canada Remote Systems
- Career Retention Specialist
- Carrier Routing System
- Catholic Relief Services
- Caudal regression syndrome
- Child Rebel Soldier
- Chinese restaurant syndrome
- Chronic radiation syndrome
- Chronic rhinosinusitis
- Classic Rock Society
- Classroom response system
- Co-operative Retail Services
- Cold rolled steel
- Colorado Revised Statutes
- Commercial Resupply Services
- Commission of Railway Safety
- Common Reporting Standard
- Common reference string model
- Community Relations Service
- Compagnies Républicaines de Sécurité
- Computer reservations system
- Congenital rubella syndrome
- Congressional Research Service
- Coordinate reference system
- Cosmic Ray Subsystem
- Creation Research Society
- Croatian Register of Shipping
- Cutaneous radiation syndrome
- Cytokine release syndrome
- Cytoreductive surgery
- Oracle Clusterware
- Seychellois Creole
- Somaschi Fathers
- The Game (1997 film)