CP-809101

CP-809101 is a drug which acts as a potent and highly selective serotonin 5-HT_2C receptor full agonist. It had promising results in animal models of obesity and psychosis, but associated with genotoxicity which means that future use will be restricted to scientific research applications only.
The drug has more than three orders of magnitude lower potency as an agonist of the serotonin 5-HT_2A receptor compared to the serotonin 5-HT_2C receptor as well as lower efficacy at the receptor in comparison. It did not produce the head-twitch response in rodents, and was able to antagonize the head-twitch response induce by the psychedelic drug -DOI.