CNL
- Allensworth State Park station
- CNL Financial Group
- CONCACAF Nations League
- Canadian Nuclear Laboratories
- Canley railway station
- Cannon Lake (microprocessor)
- Centre national du livre
- Chalk River Laboratories
- Chronic neutrophilic leukemia
- CityNightLine
- Clinical nurse leader
- Columbia, Newberry and Laurens Railroad
- Compute Node Linux
- Computer Networks Laboratory
- Controlled natural language
- National Literature Centre
- Northern Lighthouse Board
- Sindal Airport