CLDN18
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins.
CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells.
Clinical significance
Isoform 2 is abundant in gastric tumors.Zolbetuximab targets Claudin 18.2 to help treat gastric and gastroesophageal junction cancers.