CHFR

E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.
CHFR is recruited to sites of DNA [damage (naturally occurring)|DNA damage] and participates in the DNA damage response. CHFR has an important role in the survival of male premeiotic germ cells. About 30% of male CHFR knockout mice are infertile. In these knockout mice spermatogenesis onset is delayed and apoptosis in premeiotic germ cells is significantly increased. When these mice are 3 months old there is a complete loss of germ cells in their testes.