CEACAM5

Carcinoembryonic antigen-related cell adhesion molecule 5 also known as CD66e, is a member of the carcinoembryonic antigen gene family.

Functions

In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen, a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer. Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells. Also, it plays a significant role in the inhibition of differentiation and apoptosis in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells. High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous non-small cell lung cancer detectable via IHC.