CDE
- Cable discharge event
- California Department of Education
- Carbon dioxide equivalent
- Center for Distance Education
- Certified diabetes educator
- Chenchu language
- Chengde Puning Airport
- Ciudad del Este
- Coeur Mining
- Collaborative Development Environment
- Colorado Department of Education
- Commandement de l'Espace
- Common Desktop Environment
- Concept development and experimentation
- Dart (programming language)
- IIIT Hyderabad
- Jewish Democratic Committee
- National FFA Organization
- Payment Card Industry Data Security Standard
- Portuguese Democratic Movement