CD78

CD78 is a protein expressed on the surface of some immature and all mature B-cells. It is considered a pan-B cell antigen. Other names include Cdw78, Ba antigen, Leu21 and LO-panB-a.

Function

It is part of the MHC class II.

Expression

CD78 is expressed on all stages of B cell development from pre-B cell through plasma cells. Its expression is strongest on activated B cells.
It is also present on tissue macrophages and on epithelial cells.

Clinical significance

With flow cytometry, it can be used to detect B cells during many stages of their development. It is one of relatively few markers usefully expressed on plasma cells, and when combined with detection of markers such as CD22, can be used to determine the relative proportion of plasma cells.