CBLB (gene)

CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family.

Function

CBL-B functions as a negative regulator of T-cell activation. CBL-B expression in T cells causes ligand-induced T cell receptor down-modulation, controlling the activation degree of T cells during antigen presentation.

Clinical significance

Mutation of the CBLB gene has been associated with autoimmune conditions such as type 1 diabetes.

Interactions

CBLB has been shown to interact with: