Butaperazine


Butaperazine is a typical antipsychotic of the phenothiazine class. It was approved in 1967, and possibly discontinued in the 1980s.

Synthesis

Butaperazine can be synthesized starting from 2-butyrylphenothiazine. It is prepared in a manner that is comparable to the method used in the synthesis of propiomazine and propiopromazine. The phenothiazine is alkylated with 1--4-methylpiperazine, which is prepared in the conventional way by alkylating 1-methylpiperazine with 1-bromo-3-chloropropane.