Brian O'Connor

• Brian O'Connor (baseball coach), head coach of the Mississippi State University baseball team
• Brian O'Connor (musician), bassist for rock band Eagles of Death Metal
• Brian O'Connor (cricketer), Queensland opening bowler of the 1930s
• Brian O'Connor (philosopher), Irish social philosopher
• Brian O'Connor (pitcher), former Major League Baseball pitcher for the Pittsburgh Pirates
• Brian O'Connor (actor), actor/comedian who played Schemer on Shining Time Station
• Brian O'Connor (artist), American visual artist